| Pair Name | Delta-Tocotrienol, Docetaxel | ||
| Phytochemical Name | Delta-Tocotrienol (PubChem CID: 5282350 ) | ||
| Anticancer drug Name | Docetaxel (PubChem CID: 148124 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Delta-Tocotrienol, Docetaxel | |||
| Disease Info | [ICD-11: 2C82.0] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Necroptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Phosphorylation | RIPK1 | hsa8737 | |
| Up-regulation | Phosphorylation | MLKL | hsa197259 | |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Up-regulation | Phosphorylation | RIPK1 | hsa8737 | |
| In Vitro Model | DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 |
| PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
| Result | The ability of δ-TT to induce necroptotic cell death may represent a promising therapeutical approach to overcome DTX chemoresistance in PCa. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells. Int J Mol Sci. 2023 Mar 3;24(5):4923. doi: 10.3390/ijms24054923. | Click |
